What do you take into account when you hire talent or choose co-founder?

Yesterday, I asked a question on one of my social media accounts that sparked a great discussion. I'll try to rephrase and tweak it a bit.

My question was:
"Why is it so difficult to get a remote job offered by a U.S. company?"

Many responses mentioned factors like:

– cultural background,

– time zone differences,

– geographical proximity,

– U.S. vs. EU law,

– optimising costs (e.g. instead of hiring from the EU, they hire from Asia).

I want to look at this from the perspective of HR or those involved in hiring.

How do you approach to hiring process or teaming up with co-founders when there is distance?