Do digital 3D mockups actually prevent folding mistakes?

The folded panel alignment issue is the absolute worst.

You stare at the flat die line template on your screen for hours and then you get a physical sample back only to realize the back artwork is upside down or sitting on the side crease.

Even with 3D preview tools, printers sometimes interpret the fold lines differently depending on how the stock is fed. Do you rely on physical dummy boxes cut out on a plotter or do you trust digital renders before sending the final PDF?