Sales reps: how do you decide which leads to follow up with when your inbox has 150 threads?

Account managers and sales reps I've spoken to describe the same morning routine:

Open inbox. Feel overwhelmed. Start with whatever's on top. Miss three things that mattered.

The pipeline suffers not because of effort. It suffers because prioritization at inbox level is nearly impossible without a system.

What's your actual process? Do you use your CRM to decide, or do you work the inbox directly? Any tools or rules that actually help?

Genuine question. Building in this space and trying to understand what actually works in practice vs theory.