Launched this week
SeqBench
Sequence workbench for cloning, CRISPR, primers + MCP/API
14 followers
Sequence workbench for cloning, CRISPR, primers + MCP/API
14 followers
SeqBench is a sequence workbench for molecular and synthetic biology. SeqBench-GPT searches the literature, plans multi-step designs and drives real tool calls across primers, cloning and CRISPR, with mandatory construct verification. SeqStudio is an editable plasmid editor: features remap live as you type, with SnapGenedna/GenBank read-write, Sanger traces and virtual gels. Simulate Gibson, Golden Gate and restriction cloning, design guide RNAs, optimize codons - in batch or via REST API/MCP.
Hi everyone - I built SeqBench because the cloning-and-primer loop still means bouncing between a desktop suite, two or three web calculators, and a spreadsheet. SeqBench is one workbench for that whole loop.
SeqBench-GPT searches the literature, plans a multi-step design, and drives real tool calls across primers, cloning and CRISPR. It won't call a construct done without running verification on it first.
SeqStudio is a genuinely editable sequence and plasmid editor: every annotated feature remaps live as you insert or delete bases (including features that wrap a circular origin), with undo/redo, GenBank and SnapGene .dna read/write in both directions, a Sanger .ab1 trace viewer, and virtual gels.
Design and simulation: Gibson, Golden Gate (with junction fidelity scoring), restriction/ligation, Gateway, TOPO/TA; primer design and Tm; CRISPR guide design; ORF finder, pairwise alignment, codon optimization.
Automation: every tool is also a REST API endpoint and an MCP server, so AI agents and pipelines call the exact same calculations, and you can batch a whole multi-FASTA in one pass.
Feedback I want most is on accuracy - if a calculation disagrees with your bench result, tell me and I'll dig into it.
The live remap of features as you edit in SeqStudio is genuinely impressive, the plasmid view updates so smoothly it actually feels like designing in a proper editor rather than fighting a clunky GUI.