GS-Base is a database with spreadsheet functions that can be used for variety of tasks: from organizing your photo collections to filtering, analyzing with pivot tables and regex, cleaning, merging and joining multi-GB data sets with up to 256 million rows.
GS-Calc - a spreadsheet with 12 million rows and 16K columns that will let you make the best of your hardware.
Load e.g. 4GB+ workbooks with 0.5B cells in half a minute. Execute 12M vlookups searching 12M rows in seconds using up to 64 processor cores.