Nootrobox 2.0

Compounds with cognitive enhancing properties for your brain

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#4 Product of the DayDecember 04, 2015

Reviews

Discussion

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Julian Lehr@lehrjulian · Working on something new. Xoogler.
I'd love to hear more about the science / research behind this. The concept of nootropics sounds awesome, but I'm a little concerned about safety, side-effects and long-term effects - especially because there seem to be a lot of dubious companies in this (unregulated?) industry. I'm sure you get this from a lot of people outside the biohacking scene, what's your response? Would also like to hear from @cdixon why A16Z chose to specifically invest in Nootrobox!
Geoffrey WooMakerHiring@geoffreywoo · CEO @HVMN. Created HVMN Ketone Ester.
@lehrjulian Absolutely, there's a lot of noise with anecdotal and sample size n=1 evidence in this space. I'm also a skeptic by nature, but we're here for a reason. There's tremendously promising results from gold-standard RCT's that are published on legitimate peer-reviewed journals. The new funding will help accelerate our own R&D and clinical trials. a16z invests in technologists, and we understand that the fundamental data and research behind nootropics, cognitive modulation, and broader biohacking is constantly evolving and improving. Thus, our products and formulations are continuously updated to integrate the latest science and research. We're laser-focused on product innovation and the science behind it from not just the consumable product but all ancillary biohacking tools of which software is key. In a nutshell, I think we're bringing Silicon Valley aesthetics to the wild west of nootropics and biohacking, very much like how Lyft/Uber did so for taxi commissions and AirBnb did for couch surfing. On a broader trend level, I think biohacking is going to be huge. I recently wrote an op-ed describing the parallels of biohacking with the early homebrew computer clubs of the 70's & 80's - http://techcrunch.com/2015/11/19... Nootropics and biohacking intersects a lot of regulatory regimes. We currently are fully regulated under the dietary supplements and food products regime. We're actually vocal advocates for "smarter" regulation as the space continues to grow and evolve - http://techcrunch.com/2015/05/22... Check out our Biohacking Guide - https://nootrobox.com/biohacker-.... @rchenmit and Sumeet Sharma who're both MD/PhD candidates on the team are writing scientific consensus notes on what cognition actually is, what the aspects are, and the ways to modulate them. Peer-reviewed articles are cited.
Matt Gibson@mattkgibson · Founder of SCR
@geoffreywoo @lehrjulian The science/research behind nootropics is still lacking. Read this for an honest look at the science - https://www.sciencebasedmedicine...
Geoffrey WooMakerHiring@geoffreywoo · CEO @HVMN. Created HVMN Ketone Ester.
@mattkgibson @lehrjulian thanks for sharing the post. The author makes decent points, but I believe he paints with overly broad strokes and with an overly pessimistic tone. Yes, people have made exaggerated claims. Yes, people may over-extrapolate results in aging or sick people to healthy adults. And of course, healthy diet, exercise, and sleep are definitely some of the easiest, low-hanging fruit to pick to gain performance. But behind all the noise exists legit, sensible, and reasonable results, and that's where we choose to focus our time and energy on. I'd encourage you to look at the research behind a couple compounds we use like https://nootrobox.com/biohacker-... and https://nootrobox.com/biohacker-.... I think the notion of enhancing our cognition is a worthy goal to work towards. And lastly, in terms of regulation, we've thought a lot about how regulation should evolve as enhancement - as differentiated from therapeutics - becomes more and more mainstream. Read our thoughts on Techcrunch here - http://techcrunch.com/2015/05/22...
Matt Gibson@mattkgibson · Founder of SCR
@geoffreywoo @lehrjulian While I think the goal itself is worthy to work towards, I think you should do better at separating good science from poor science when you cite evidence for your claims. For example you have decided to cite the Journal of Alternative and Complementary Medicine at least 3 times, that particular science journal is probably the least reputable journal (which should be obvious by its name) out there. Another example is the fact that caffeine is used alongside Theanine in most of the papers/articles you cite for "The Effect of Theanine on Attention" - which means that realistically it is caffeine (a stimulant) that is doing the heavy lifting, not theanine.
Geoffrey WooMakerHiring@geoffreywoo · CEO @HVMN. Created HVMN Ketone Ester.
@mattkgibson @lehrjulian No, it's not just measuring caffeine. The L-theanine + caffeine stack performs superior to placebo AND caffeine control groups. We fully stand behind our products and our model to be driven by the compounds that have the best science behind them and that can be legally sold for human consumption without prescription and with low side effect profiles. And for picking out journals, you're really stretching here. We've cited dozens of studies including ones in Biological Psychology and other great journals. We're very comfortable with the data that we're basing our products on, and we're keen on generating more basic science. Appreciate the thoughtful questions though. It keeps us sharp.
CWilson@cmwilson15 · Indie Developer, Follow The Circle
Thync, TruBRAIN, and Neurovigil are way more legit than you guys. To call yourselves category leaders and ignore Reddit criticism on your stacks is cowardly. Those other teams have actual horsepower on the management teams and you guys have no science credentials and no science behind these products, which aren't really nootropics (green tea has caffeine and l-theanine already). Pretty weak.
Geoffrey WooMakerHiring@geoffreywoo · CEO @HVMN. Created HVMN Ketone Ester.
@cmwilson15 Hey, we're here. Bring up your critical feedback here. We don't ignore any threads on purpose, and we constantly improve our offerings. RISE and SPRINT are already on their 2nd version, etc. I think what Thync is doing with TCDS is interesting, which is adjacent to what we're doing with nootropics. There's some promising but conflicting data there, and I'd like to see them release their peer-reviewed data purely as a consumer. I have no dog in that fight for wearable TCDS of which they're one player. This is not something Nootrobox will pursue. Trubrain I actually have some opinions about. They're actually breaking FDA regulations by selling research chemicals i.e. racetams for human consumption, and if they're willing to do that, I'm not sure what other regulations they're really skirting with. I don't know anything about neurovigil. You may be referring to nuvigil, which is a prescription narcolepsy drug, and a precursor to modafinil. This is a prescription drug with side effect profiles that should be monitored by a medical professional. We're category leaders because we understand and are thoughtful from a manufacturing and regulatory perspective, and have a strong opinion on how the future of enhancement will unfold. We publish thought pieces and are widely syndicated. That's why we're leaders. Thanks.
CWilson@cmwilson15 · Indie Developer, Follow The Circle
@geoffreywoo No, Neurovigil. They have a great team, backed by DFJ and others. I don’t see you guys as reputable in the biohacking space and reckon you make it more snakeoil-ish, not less. No bachelor's or advanced degrees in science and formulas that are essentially tea plus herbal Prozac..seems very sketchy of your team to be packaging herbal anti-depressants. You claim to be battling against infomercial types but with the typical “panel” of uninvolved scientists (not actually on the team), a bunch of planted positive comments and questions from your friends, nothing new in the stacks, over priced and low efficacy vs. what you can get from the web, and this is refreshing and different?
Geoffrey WooMakerHiring@geoffreywoo · CEO @HVMN. Created HVMN Ketone Ester.
@cmwilson15 you clearly don't know who we are and who are team is. watch this to learn more - http://www.bloomberg.com/news/vi...
Niv DrorHiring@nivo0o0 · Words @ProductHunt & @AngelList
Big fan of Nootrobox! Congrats on the investment @cdixon and to @geoffreywoo and the team for making an awesome product. Happy customer of Rise for a few months now :) I'm curious about the newer products you've rolled out, Sprint, Rise, and the GO CUBES -- can you tell us a little more about them? (And about Rise as well 😊)
Geoffrey WooMakerHiring@geoffreywoo · CEO @HVMN. Created HVMN Ketone Ester.
@nivo0o0 thanks for the kind words Niv! We're excited to work with @cdixon and @a16z to build a truly iconic nootropics and biohacking company here. When we say that we bring Silicon Valley aesthetics to biohacking, what does that mean exactly? It means constant, continuous iteration - a notion that hasn't reached nootropics and the broader supplements / CPG / foods industries. We understand that the fundamental data and research behind nootropics, cognitive modulation, and broader biohacking is constantly evolving and improving. Thus, our products and formulations are continuously updated to integrate the latest science and research. A little about the products themselves - RISE is your daily nootropic, SPRINT is your short-term focus boost, YAWN is for optimizing sleep, and GO CUBES (which is on pre-order) is the SPRINT stack in 'chewable coffee' form factor. We're already on our 2nd versions of both RISE and SPRINT and are collating community feedback and the latest research to update YAWN and GO CUBES. The @nootrobox team and I will be around this Hunt for the day, so drop us a line and kick our tires :)
Jack Smith@_jacksmith · Serial Entrepreneur & Startup Adviser
@geoffreywoo massive congrats on the new funding. I have no doubt that Chris will be an awesome partner to help take you to the next level.
Geoffrey WooMakerHiring@geoffreywoo · CEO @HVMN. Created HVMN Ketone Ester.
@_jacksmith @cdixon is a boss.
Drew Lawrence@drewlawrence · Director of Business Development
@geoffreywoo - I've been following you guys for a while, but am inherently skeptical of the benefits. As such, I've avoided taking the leap and dropping the $ to give it a go. Nothing personal, you just see too many of these 'magic pills' all over the place. Have you thought about offering a free 1 month supply w/ a sign up? Put the burden on your customers to unsubscribe once they sign up, but offer enough of a sample for effects to be realized in order to establish the value.
Geoffrey WooMakerHiring@geoffreywoo · CEO @HVMN. Created HVMN Ketone Ester.
@drewlawrence Absolutely, there's a lot of noise with anecdotal and sample size n=1 evidence in this space. I'm also a skeptic by nature, but we're here and working hard for a reason. There's tremendously promising results from gold-standard RCT's that are published on legitimate peer-reviewed journals. The new funding will help accelerate our own R&D and clinical trials. We understand that the fundamental data and research behind nootropics, cognitive modulation, and broader biohacking is constantly evolving and improving. Thus, our products and formulations are continuously updated to integrate the latest science and research. Also check out our Biohacker Guide - https://nootrobox.com/biohacker-.... @rchenmit and Sumeet Sharma who're both MD/PhD candidates on the team are writing scientific consensus notes on what cognition actually is, what the aspects are, and the ways to modulate them. Peer-reviewed articles are cited. We've played around a little bit with various sample programs. Honestly though, a typical user path is to try a bottle of SPRINT or YAWN, and then grow into other stacks. We'll look into how we can sensibly get more of our product into more people's hands.
Drew Lawrence@drewlawrence · Director of Business Development
@geoffreywoo Thanks for the reply. I'll give it a go and promise that I'll provide some candid feedback. :-)