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Elysium Health

Anti-aging pills

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Eric Marcotulli@eric_marcotulli · Founder/CEO of Elysium Health
Eric Marcotulli, CEO of Elysium Health here. I appreciate the thoughts and ideas offered on this page, and I wanted to provide some of mine in return, as well as answer some of the questions that were outlined. Efficacy + Clinical Data. Elysium’s mission is to solve the biggest challenges in health. That cannot be done without conducting rigorous clinical research and actually assuming the responsibility of pushing that research forward. In February 2016, we submitted to ClinicalTrials.gov the protocol for the first human study of our product Basis: – a placebo-controlled, double-blind, randomized study of 120 healthy individuals between the ages of 60 and 80. (The age bracket was chosen based upon the fact that these individuals would be the most depleted in their levels of NAD+, the critical coenzyme that declines as we age and is the target of Basis). We posted it not only because we wanted to demonstrate our dedication to a rigorously architected study, but because we are also committed to transparency.   We concluded the study a few months ago, and we have since analyzed the data and drafted a manuscript that we are submitting for the peer-review process – again, because we want to meet and exceed the standards typically found in our broader market. This past week, we announced the topline results of that study: • In the bracketed age group, study participating taking our recommended dose of Basis saw an average increase in NAD+ levels of 40% in the first 30 days and kept that increase constant at 60 days. This equates to NAD+ levels those individuals would have had during their youth.  • The p value for this change was <0.01. • The placebo group did not see a change at all.  • There were no material adverse events, and the product was well tolerated. This is important in that, for the first time ever, it was demonstrated that a product, Basis, can safely increase and sustain NAD+ levels. The remainder of our findings and full study analysis will be published in the months ahead. I am happy to see such fervor regarding the need for these studies, and you will see more of them related to Basis and our pipeline products. In fact, a significant amount of our recently announced funding will go toward clinical research conducted at top tier institutions and focused on high-severity areas in human health.
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Kumar Thangudu@datarade · Technologist
Elysium Health is claiming to be more scientific than other supplements companies, but they are selling their products before doing the trials. This is a Nootrobox clone. Look at the team pedigree. Probably nice dudes, but they have no place in biochemistry. They'll never subject themselves to actual scientific scrutiny, because they know the entirety of the scientific community would lambast them. Nobel Laureautes is a red flag for false proxies in biochemistry. They recruited a subpar scientist just for marketing purposes. This MIT Leonard P. Guarente guy has a nearly 20 year history of bad runs at labs. Have a look here: http://science.sciencemag.org/co... A study on worms can not be translated to humans...even mouse studies dont translate...even chimp studies don't translate. But they are a needed stepping stone. If these companies are spouting that they are being more scientific and believe what they are selling then they should get the proof first...just like real drug companies that have to get FDA approval to make their claims. It’s likely that some of these supplements have minor but perceptible effects and in synergy they have measurable effects, but bypassing the FDA to demonstrate this is not the way to go (the FDA also needs to modify its criteria for efficacy, but that’s another discussion).
Chris@coolbearcjs · CEO
@datarade Why so much hate for a team that has failed in the past...Failure is a great teacher and not a sign of someone who can never succeed...You seem like you want to hate them because they are going into the same space as your pet company Nootrobox which is fine yet let these guys deliver a product and test it out before you hammer them so hard with such venom...I for one will wait and see what they deliver...
Avery Haskell@averyhaskell · Stanford Computer Science
@datarade They raised 20 million from top decile VC'S. Hence, they're legit
Tyler Hayes@thetylerhayes · Bebo
@coolbearcjs @datarade Kumar's feedback style isn't for everyone, especially here at PH where we try to be constructive and supportive even in disappointment and criticism, but his logic is sound. I have a neuroscience degree, and in my experience following Kumar he knows more than enough to speak with authority here. There's also a big difference between failing to try and failing to succeed. You can fail to succeed, and good on you. Failing to try is not ok in startups because you're playing with people's time and money. In hard sciences like biology and neuroscience when you fail to try—specifically, fail to even do basic accepted scientific practice (let alone legal practice like getting approved by the FDA)—you're playing with people's health and lives. There is a higher bar in science for a reason.
Kumar Thangudu@datarade · Technologist
@averyhaskell That's so false. I can provide multiple examples: Nootrobox - it wouldn't pass a basic litmus test of scientific experts/researchers. - funded by A16Z Lumosity - Fundedy by MenloVentures. It is mostly bad science. I understand your desire to continue defending other Stanford CS majors, I imagine it helps your cause, but please understand it could have harmful effects upon consumers. I would fight anti-vaxxers tooth and nail, I'll also do the same to these quacks. They're welcome to come out and call me out on my BS, if I'm actually full of BS. I'm totally okay with that, but the reality is that, they won't, because they cannot honestly stand behind the data they're extrapolating into claims.
Avery Haskell@averyhaskell · Stanford Computer Science
@datarade Theranos though. Sorry that science is slower than business creation
kurt braget@kurtybot · developer, entrepreneur
@datarade i would be interested in what the founder's response is to this, seems like a legitimate concern.
Ryan Hoover
Hunter
@rrhoover · Founder, Product Hunt
TechCrunch's @sarahbuhr just scooped their recent funding in the amount of $20m. From the article: "But are Elysium’s pills really the fountain of youth? Elysium claims its Basis product can do anything from helping you sleep better to repair your DNA, all leading up to a longer, healthier life. But the ingredients in these pills — a combination of nicotinamide riboside (NR) and pterostilbene — are not proprietary. For one they occur naturally in blueberries and milk, and for another you can actually buy both ingredients used in Elysium’s pills in separate bottles on Amazon for around $19 for a 30-day supply of NR and $12 for a 60-day supply of pterostilbene. The site describes them as pills that make you feel young, not necessarily anti-aging pills. This is a wild space that's getting more attention, from VC's and founders, bringing to question science, morality, and sci-fi futures. 😱 Update: The team just announced this statement, clarifying their Series B backed by General Catalyst.
joshua bradley@airjoshb · Celebrating people, making life better.
@rrhoover the funny thing about many of these supplements is the base ingredients are often patented and available from multiple sources making it a marketing game. Thorne Research is doing/has done some solid research in this space and has a good product I've been using for several months made from the same patented NR ingredient for a lot less.
Kumar Thangudu@datarade · Technologist
The whole “sirtuins are important determinants of aging” field is looking more and more like a giant steaming pile of bad science, with Guarente/Sinclair at the helm. At some point we have to look beyond the place of work (Harvard/MIT), beyond the journals where most of this is published (Cell/Nature/Science), beyond the whole Boston VC/Biotech jumps of joy, and call a spade a spade. Giving credence to scientific quacks is a disservice to the PH community. At this point, the best we can hope is Elysium will do for Guarente what Rejuvenon did for Bruce Ames. Founder of scientific field? Meet 10ft pole.
Dimo Trifonov@denull · Founder of @feeld
Whatever these pills do, I really don't trust them but I could see how some people will try the quick fix. I see how they are trying to hide their shady product behind a fancy brand. That page screams scam https://www.elysiumhealth.com/te...
@denull wow shady indeed
Evan Kimbrell@evankimbrell · Founder, Sprintkick
Interesting branding choice. But then again a meal replacement startup called themselves Soylent....
Cody@rdbrdd · Owner of Redbearded
@evankimbrell For reals. If food named Soylent can make it anything can...