HKDCThe solution to a bloated Twitter Follow list usually involves the Twitter user going through the entire list and unfollowing individuals one by one. If that sounds like too much work, there's an extension for Chrome called Twitter Unfollow that adds a "Mass Unfollow' button to the Twitter page.
LifehackerChrome: If you're looking to start fresh on Twitter and just want your feed to be a blank slate, Twitter Unfollow purges your entire follow list with just one click. Finally, some peace and quiet. There are a number of reasons why you'd want to start from scratch.