Refined Twitter improves the Twitter experience by removing cruft and adding useful features.
Available for Chrome, Firefox, Opera.
Some of the best features are: Embedding linked Instagram photos directly in the tweet, syntax highlighting of code blocks, auto-loads new tweets in the stream if you're scrolled to the top, removes promoted tweets.
Tweeten is a column-based interface that helps you keep track of everything that's happening on Twitter without needing to hit the refresh button.
Gorgeous Mac client for Twitter, based on the mobile Twitter website. It has a beautiful and minimal interface, a convenient standalone Tweet composer, and it supports common macOS shortcuts. It also has a status bar icon for quick access.
Stack is a mac application for all your social media web apps.